Health News Update

Orlistat an Effective Weight loss Pill

Weight loss medication in the most recent health news is something known as Orlistat. There are not many prescription based weight loss pills on the market but Orlistat, also known as Xenical is one of the latest. Orlistat has been around for at least a decade and is claimed to promote weight loss by preventing digestion and absorption of fat in the intestine.

All fat when ingested is broken down by an enzyme released from the pancreas. The pancreas releases the enzyme lipase which breaks up the fat which can then be absorbed from the intestine into the body. Orlistat acts by blocking the lipase enzyme so that the fats are not broken down and hence not absorbed. The blockage on the lipase enzyme is not 100% but average about 50%-75%. The unabsorbed fat is then excreted into the stools.

Orlistat has been approved by the FDA for use in North America. There is also a lower dose of the drug available over the counter. The generic brand name sold over the counter is known as Alli and requires no prescription.

For weight loss, Orlistat has to be taken on a daily basis for 2-3 months. However, the pill itself does not always work in all individuals. Physicians recommend that Orlistat must be combined with exercise and a reduced intake of calories for the medication to have the most benefits. If the patient is suffering from weight gain as a result of hormone imbalance, the patient must first stabilize hormone levels and follow a hormone diet which achieve weightloss. The drug is often prescribed for individuals who are moderately obese (BMI > 25 kg/m2).

Studies indicate that the average weight loss with Orlistat after six months averages about 12-15 pounds.

The prescription pill (120mg) is taken three times a day, one hour before each meal.
Because Orlistat inhibits fat absorption, patients taking fat soluble vitamins (A, D, E, K) should not take Orlistat at the same time.

While Orlistat is generally a safe drug it does have a few unpleasant side effects. The most common side effect includes soiling of the underwear. The soiling is from the unabsorbed fat which can occur at any time. Passage of excess gas, loose and oily stools is also common. Some individuals also develop abdominal cramps and bloating. The inability to control bowel movements is also a common complaint. These side effects do not occur in all individuals but when they do occur, they are disturbing. The side effects generally start a few weeks after starting treatment and in a few patients may resolve. However, in the majority of individuals the symptoms will persist as long as the pill is taken. To decrease the side effects, it is recommended that one eat a low fat diet and decrease the dose of Orlistat.

A rare side effect of the drug is the development of kidney stones.

Orlistat is not an inexpensive product. The average cost for 30 pills is about $60-$90. And remember one takes 3 pills a day and so it is an expensive undertaking with no guarantee of any benefit plus a definite chance of developing some type of side effect.

Speak with your physician if you feel you would like to try this medication before you embark on your weight loss program.