Health News Update

“Calcium supplements, which many people consume hoping to ward off osteoporosis, may increase the risk of heart attack by as much as 30 percent, researchers reported Friday.

These tiny tablets which carry concentrated doses of calcium were also associated with higher incidences of stroke and death, but they were not statistically significant.

The researchers advised people consuming calcium supplements to seek advice from their doctors, take more calcium-rich foods and try other interventions like exercise, not smoking and keeping a healthy weight to prevent osteoporosis.

“People regard calcium supplements as natural but they are really not natural at all,” Ian Reid, professor of medicine at the University of Auckland in New Zealand, said in a telephone interview.

Reid and colleagues in Britain and the United States conducted a meta-analysis encompassing 11 studies that tracked nearly 12,000 elderly people over four years.

Half of them were given calcium supplements and the other half placebo or dummy pills with no therapeutic content. The results were published in the British Medical Journal.

“What we found was a 30 percent increase in heart attacks in the people who were randomized to take calcium,” Reid said.
“If you have 1,000 people taking calcium for five years, we will expect to find 14 more heart attacks, 10 more strokes and 13 more deaths in the people given calcium than they would have had if they hadn’t been treated with calcium,” Reid said.

“That is 37 more adverse events and we expect 26 fractures being prevented. So calcium is associated with more bad things happening than with bad things prevented.”

While experts are not certain about the biological mechanism by which calcium supplements may damage the body, studies in the past have linked high levels of blood calcium to more heart attacks and damage to blood vessels, Reid said.

“When you take calcium supplements, your blood calcium level goes up over the following four to six hours and goes up to the top end of the normal range,” he said.

“That doesn’t happen when you have calcium to eat in your diet because the calcium from food is very slowly absorbed and so the blood calcium level hardly changes at all.”

Higher blood calcium may lead to the formation of plaques in blood vessels, which can lead to heart attack, stroke and other cardiovascular diseases, Reid explained.

“People have always focused on fat levels in the blood as driving that process (plaque formation) but there is increasing evidence now that calcium levels in the blood might drive that as well,” he added.”

Chauhan and colleagues have developed a new extended-release delivery approach incorporating vitamin E into contact lenses. The invisible clusters, or aggregates, of vitamin E molecules form what Chauhan describes as “transport barriers.” that slow down the elusion of the glaucoma medication from the lens into the eye. The drug released from the lens into the eye stays in the tears far longer than the 2-5 minutes with eye drops, leading to more effective therapy.

“These vitamin structures are like ‘nano-bricks’,” Chauhan said. “The drug molecules can’t go through the vitamin E. They must go around it. Because the nanobricks are so much bigger than the drug molecules — we believe about a few hundred times bigger — the molecules get diverted and must travel a longer path. This increases the duration of the drug release from the lenses.”

In research with laboratory animals, the lenses containing vitamin E nanobricks administered drugs up to 100 times longer than most commercial lenses. The lenses could be designed for continuous wear for up to a month, Chauhan said. In addition to treating glaucoma, the contacts could help other eye conditions, such as cataract and dry eye. Cataract is a clouding of the lens of the eye, and dry eye involves decreased production of tears. It affects about 2 in 10 people and can lead to more severe eye problems.

“Vitamin E is a proven nutraceutical that in small amounts is good for the eye because of its ant-oxidant properties. Also Vitamin E presence in the contact lenses blocks UV radiation, leading to increased protection against the UV light. Our research has shown that the vitamin can be loaded into the lenses without any reduction in transparency. We believe it could be helpful in disease treatment and in prevention as well,” he said.

“We have developed a novel approach of extending the duration of drug release from contact lenses by including nanosized aggregates of Vitamin E in the lenses. The Vitamin E nano-aggregates force the drug molecules to travel in a tortuous path leading to increased drug release durations. Another benefit of Vitamin E incorporation is that Vitamin E is known to be an anti-oxidant, whose slow release from lenses could also help in prevention of ophthalmic diseases like cataract and glaucoma.

Furthermore, Vitamin E blocks UV radiation, leading to reduced ocular damage from the UV light. Our research has shown that Vitamin E can be loaded into the lenses without any reduction in transparency. The drug release durations from Vitamin E loaded lenses are about 100 times longer than from commercial lenses for several ophthalmic drugs including glaucoma drug timolol, anti-inflammatory drug dexamethasone, and anti-viral drug flucanozole. Thus, Vitamin E loaded lenses could be highly effective in synergistic prevention and treatment of ophthalmic diseases through extended delivery of the desired drugs and the nutraceutical Vitamin E. Animal studies in beagle dogs are ongoing to explore glaucoma treatment through Vitamin E laden contact lenses.”